Ginkgolide B

Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments[1][2].

Product Specifications

CAS Number

[15291-77-7]

Product Name Alternative

BN-52021

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Platelet-activating Factor Receptor (PAFR) ; Pregnane X Receptor (PXR)

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Ginkgolide-B.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 100 mg/mL

Smiles

O[C@@H]1C(C2([C@H]3O)[C@](OC3=O)([H])O4)([C@@](O5)([H])C[C@H]2C(C)(C)C)C4(C5=O)[C@@](O)([C@@H]6C)[C@@]1([H])OC6=O

Molecular Formula

C20H24O10

Molecular Weight

424.40

Precautions

H315, H319, H335

References & Citations

[1]Tao Zhou, et al. Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. Acta Pharmacol Sin. 2016 Feb;37 (2) :177-86. |[2]Pei-Dong Zheng, et al. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13 (7) :1204-1211.