XMD8-92
XMD8-92 is a potent ERK5 (BMK1) /BRD4 inhibitor with Kds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with Kds of 190, 600 and 890 nM, respectively. Anti-cancer activity[1][2].
Product Specifications
CAS Number
1234480-50-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CaMK; Epigenetic Reader Domain; ERK; TNK1
Type
Reference compound
Related Pathways
Epigenetics; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xmd8-92.html
Purity
99.48
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(C1=O)C2=CN=C(N=C2N(C3=C1C=CC=C3)C)NC4=C(C=C(C=C4)N5CCC(CC5)O)OCC
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; DCAMKL; ERK5
Available Sizes
Frequently Asked Questions
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