Alectinib-d6
Alectinib-d6 is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
Product Specifications
CAS Number
1616374-19-6
Product Name Alternative
CH5424802-d6; RO5424802-d6; AF802-d6
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.05
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NC3=CC(C#N)=CC=C32)C(C([2H])([2H])[2H])(C4=CC(N5CCC(N6CCOCC6)CC5)=C(CC)C=C41)C([2H])([2H])[2H]
Molecular Formula
C30H28D6N4O2
Molecular Weight
488.65
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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