α-Triglycidyl isocyanurate
α-Triglycidyl isocyanurate (Teroxirone) is an antitumor compound with activity to inhibit DNA replication. α-Triglycidyl isocyanurate exerts its anticancer effect by alkylating and cross-linking DNA. α-Triglycidyl isocyanurate is relatively stable in fresh human plasma and whole blood, showing good biocompatibility. The metabolism of α-Triglycidyl isocyanurate mainly occurs in rat liver and is metabolized through an NADPH-independent pathway. The cytotoxicity of α-Triglycidyl isocyanurate can be partially restored under specific conditions, suggesting the complexity of its metabolic pathway[1].
Product Specifications
CAS Number
59653-73-5
Product Name Alternative
Teroxirone
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α-triglycidyl-isocyanurate.html
Smiles
O=C(N(C(N(C1=O)C[C@H]2CO2)=O)C[C@@H]3CO3)N1C[C@@H]4CO4
Molecular Formula
C12H15N3O6
Molecular Weight
297.26
References & Citations
[1]Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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