PROTAC SGK3 degrader-1
Product Specifications
Product Name Alternative
SGK3-PROTAC1
UNSPSC Description
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate)[1].
Target Antigen
PROTACs; SGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-sgk3-degrader-1.html
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=C(C=C(C=C1)C)S(=O)(NC2=CC=C(C=C2)C3=NC4=C(C(OC[C@H]5CN(CCO5)CCCCCCOCCOCCOCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=N3)C=NN4)=O
Molecular Weight
1157.38
References & Citations
[1]Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125878/PROTAC-SGK3-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125878/PROTAC-SGK3-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2381320-35-8
Available Sizes
Curated Selection
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