N6- (2-Phenylethyl) adenosine

N6- (2-Phenylethyl) adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively[1].

Product Specifications

CAS Number

[20125-39-7]

Product Name Alternative

N6-Phenethyladenosine; N6-Phenylethyladenosine

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/N6-_2-Phenylethyl_adenosine.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 50°C)

Smiles

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3NCCC4=CC=CC=C4)O1)O)O

Molecular Formula

C18H21N5O4

Molecular Weight

371.39

References & Citations

[1]Tchilibon S, et al. Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6- (2-phenylethyl) adenosine derivatives as potent ligands. Bioorg Med Chem. 2004 May 1;12 (9) :2021-34.