Serine Palmitoyltransferase 1
Product Specifications
Background
Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses. Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells. Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract. Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.
Synonyms
Long chain base biosynthesis Protein 1, LCB-1, LCB1, Serine-palmitoyl-CoA transferase 1, SPT1, SPT 1, SPT-1
UniProt
O15269
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB, IHC
Field of Research
Signal Transduction
Assay Principle
For use with serine palmitoyltransferase 1 polyclonal antibodies (Cat. No. X1862P , X2066P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
Antibody Function Blocking
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