(S) -Roscovitine
(S) -Roscovitine ((S) -Seliciclib; (S) -CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S) -Roscovitine shows neuroprotective efficacy. (S) -Roscovitine has the potential for the research of stroke[1][2].
Product Specifications
CAS Number
186692-45-5
Product Name Alternative
(S) -Seliciclib; (S) -CYC202
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-roscovitine.html
Concentration
10mM
Purity
99.15
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC[C@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
Molecular Formula
C19H26N6O
Molecular Weight
354.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10 (1) :104.|[2]Menn B, et al. Delayed treatment with systemic (S) -roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5 (8) :e12117.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; CDK7; CDK9
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