(S) -Roscovitine

(S) -Roscovitine ((S) -Seliciclib; (S) -CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S) -Roscovitine shows neuroprotective efficacy. (S) -Roscovitine has the potential for the research of stroke[1][2].

Product Specifications

CAS Number

[186692-45-5]

Product Name Alternative

(S) -Seliciclib; (S) -CYC202

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-roscovitine.html

Concentration

10mM

Purity

99.15

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC[C@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO

Molecular Formula

C19H26N6O

Molecular Weight

354.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10 (1) :104.|[2]Menn B, et al. Delayed treatment with systemic (S) -roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5 (8) :e12117.