FGFR4-IN-5
Product Specifications
UNSPSC Description
FGFR4-IN-5 is a potent and selective covalent FGFR4 inhibitor with an IC50 of 6.5 nM. FGFR4-IN-5 exhibits strong anti-tumor activity in vivo and can be used for hepatocellular carcinoma research[1].
Target Antigen
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-5.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1C2=NC(N[C@@H]3COC[C@@H]3NC(C=C)=O)=NC=C2C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C1=O
Molecular Weight
520.37
References & Citations
[1]Haibo Liu, et al. Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131704/FGFR4-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131704/FGFR4-IN-5-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1628793-01-0
Available Sizes
Curated Selection
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