FGFR4-IN-5
FGFR4-IN-5 is a potent and selective covalent FGFR4 inhibitor with an IC50 of 6.5 nM. FGFR4-IN-5 exhibits strong anti-tumor activity in vivo and can be used for hepatocellular carcinoma research[1].
Product Specifications
CAS Number
[1628793-01-0]
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-5.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1C2=NC(N[C@@H]3COC[C@@H]3NC(C=C)=O)=NC=C2C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C1=O
Molecular Formula
C23H23Cl2N5O5
Molecular Weight
520.37
References & Citations
[1]Haibo Liu, et al. Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. ACS Med Chem Lett. 2020 Mar 6;11 (10) :1899-1904.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
135288 50 µg
VPS72 (Vacuolar Protein Sorting-associated Protein 72 Homolog, Protein YL-1, Transcription Factor-like 1, TCFL1, YL1)
Ask
View Details NBP3-14121JF669 0.1 mL
Mouse Monoclonal MITF Antibody (PCRP-MITF-1D9) [Janelia Fluor 669]
Ask
View Details S0B0100-01 25 µL
β-actin Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (SDT-R015)
Ask
View Details S0B0100-02 100 µL
β-actin Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (SDT-R015)
Ask
View Details