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Flucopride

Flucopride (Compound 4a) is an AChE inhibitor (IC50: 24 nM), and a partial 5-HT4R agonist (Ki: 9.6 nM for (h) 5-HT4R) . Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h) 5-HT4R (EC50: 23.0 nM) . Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay) [1].

Product Specifications

CAS Number

1639925-34-0

UNSPSC

12352005

Target

5-HT Receptor; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/flucopride.html

Smiles

O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC3CCCCC3)CC2

Molecular Formula

C22H33FN2O2

Molecular Weight

376.51

References & Citations

[1]Rochais C, et al. Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease. Eur J Med Chem. 2024 Dec 15;280:116975.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; Apolipoprotein D

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