EML4-ALK kinase inhibitor 1
Selected Variant
HY-111752-01
Size: 5 mg
EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM[1].
Product Specifications
CAS Number
1373409-08-5
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EML4-ALK_kinase_inhibitor_1.html
Purity
98.02
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
CO[C@H]1CC[C@H](NC2=C(CC)N=C(C(N)=O)C(NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=N2)CC1
Molecular Formula
C31H48N8O3
Molecular Weight
580.76
References & Citations
[1]Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4) -anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27 (8) :1683-1692.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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