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dTAGV-1-NEG

Product Specifications

UNSPSC Description

dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12F36V-selective degrader[1].

Target Antigen

FKBP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dtagv-1-neg.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@H](O)C4)=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7

Molecular Weight

1247.54

References & Citations

[1]Nabet B, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11(1):4687.

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-145514A/dTAGV-1-NEG-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-145514A/dTAGV-1-NEG-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2451573-87-6

Available Sizes

Curated Selection

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