NSC45586 (sodium)
NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP) . NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].
Product Specifications
CAS Number
[6300-44-3]
UNSPSC
12352005
Target
Akt; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nsc45586-sodium.html
Purity
98.0
Solubility
H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(O[Na])C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O
Molecular Formula
C20H17N6NaO3
Molecular Weight
412.38
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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