NSC45586 (sodium)
Product Specifications
UNSPSC Description
NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].
Target Antigen
Akt; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nsc45586-sodium.html
Purity
98.0
Solubility
H2O : 5 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C(O[Na])C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O
Molecular Weight
412.38
References & Citations
[1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19820A/NSC45586-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19820A/NSC45586-sodium-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
6300-44-3
Available Sizes
Curated Selection
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