NSC45586 (sodium)

NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP) . NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].

Product Specifications

CAS Number

[6300-44-3]

UNSPSC

12352005

Target

Akt; Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nsc45586-sodium.html

Purity

98.0

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(O[Na])C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O

Molecular Formula

C20H17N6NaO3

Molecular Weight

412.38

References & Citations

[1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347 (2) :516-28.