(E) -Ferulic acid

(E) -Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E) -Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E) -Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E) -Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

Product Specifications

CAS Number

[537-98-4]

Product Name Alternative

(E) -Coniferic acid

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bcl-2 Family; Endogenous Metabolite; Ferroptosis; β-catenin

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-ferulic-acid.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C1=CC=C(O)C(OC)=C1

Molecular Formula

C10H10O4

Molecular Weight

194.19

Precautions

H315, H319, H335

References & Citations

[1]Fong Y, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016 Oct 1;11:45.|[2]Ogbuta A A, et al. Protective Effects of Trans-Ferulic acid on Tamoxifen Induced Heptatic and Renal Oxidative Stress in Male Wister Albino Rat. Journal of Applied Sciences and Environmental Management, 2023, 27 (8) : 1727-1732.