GSK3-IN-3

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA[1][2][3].

Product Specifications

CAS Number

[331963-27-0]

UNSPSC

12352005

Target

GSK-3; Mitophagy

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk3-in-3.html

Purity

99.22

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(N(CC)C2=C(C1=O)C=CC=C2)O)NNC(CCCCCCCCCCC)=O

Molecular Formula

C24H35N3O4

Molecular Weight

429.55

References & Citations

[1]Maestro I, et al. Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease. ACS Chem Neurosci. 2021 Dec 15;12 (24) :4512-4523. |[2]Morales-García JA, et al. Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease. ACS Chem Neurosci. 2013 Feb 20;4 (2) :350-60. |[3]Palomo V, et al. Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities. J Med Chem. 2011 Dec 22;54 (24) :8461-70.