VU041

VU041 is a first submicromolar-affinity inhibitor of Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC50 values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC50 of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function[1].

Product Specifications

CAS Number

[332943-64-3]

Product Name Alternative

BYK61359,WX-UK1; UKI-1C

UNSPSC

12352005

Target

Parasite; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/vu041.html

Purity

99.31

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(C1=NN(CC(N2CCCC3=C2C=CC=C3)=O)C4=C1CCCC4)(F)F

Molecular Formula

C19H20F3N3O

Molecular Weight

363.38

References & Citations

[1] Swale DR, et al. An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria. Sci Rep. 2016 Nov 16;6:36954.