5-Formyl-2'-deoxyuridine

5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein[1].

Product Specifications

CAS Number

[4494-26-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-formyl-2-deoxyuridine.html

Purity

99.64

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)C[C@H](N2C=C(C=O)C(NC2=O)=O)O1

Molecular Formula

C10H12N2O6

Molecular Weight

256.21

Precautions

H315, H319, H335

References & Citations

[1]Sugiyama T, et al. Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2′-deoxyuridine[J]. Nucleosides, Nucleotides and Nucleic Acids, 2001, 20 (4-7) : 1079-1083.