Zegocractin

Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively[1].

Product Specifications

CAS Number

[1713240-67-5]

Product Name Alternative

CM-4620

UNSPSC

12352005

Hazard Statement

H302

Target

CRAC Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CM-4620.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=NC=C(C2=C(Cl)C=C(OC(F)(F)O3)C3=C2)N=C1)C4=C(C)C=CC=C4F

Molecular Formula

C19H11ClF3N3O3

Molecular Weight

421.76

Precautions

H302

References & Citations

[1]ARYL SULFONOHYDRAZIDES. WO2016/138472Al.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

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