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Ketotifen-d3 (fumarate)

Ketotifen-d3 (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks[1][2].

Product Specifications

CAS Number

1795138-23-6

UNSPSC

12352005

Target

Histamine Receptor; Influenza Virus; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Purity

99.23

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C(=CC(O)=O)C(O)=O.O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C([2H])([2H])[2H])CC4)C=CS2

Molecular Formula

C23H20D3NO5S

Molecular Weight

428.52

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59 (9) :1213-21.|[3]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35 (1) :1322-1330.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

H1 Receptor

Available Sizes

Frequently Asked Questions

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