N, N-Dimethylglycine (hydrochloride)

N, N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N, N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N, N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects[1][2][3].

Product Specifications

CAS Number

[2491-06-7]

Product Name Alternative

Dimethylglycine (hydrochloride) ; DMG (hydrochloride) ; N-Methylsarcosine (hydrochloride)

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives; Endogenous Metabolite; iGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-n-dimethylglycine-hydrochloride.html

Purity

99.46

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CN(C)C.Cl

Molecular Formula

C4H10ClNO2

Molecular Weight

139.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Hsieh CP, et al. N, N-dimethylglycine Protects Behavioral Disturbances and Synaptic Deficits Induced by Repeated Ketamine Exposure in Mice. Neuroscience. 2021 Sep 15;472:128-137.|[2]Bai K, et al. Dimethylglycine sodium salt protects against oxidative damage and mitochondrial dysfunction in the small intestines of mice. Int J Mol Med. 2019 May;43 (5) :2199-2211. |[3]Bai K, et al. Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice. PLoS One. 2016 May 12;11 (5) :e0155393.