O-304

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

Product Specifications

CAS Number

[1261289-04-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/O-304.html

Purity

99.59

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3

Molecular Formula

C16H11Cl2N3O2S

Molecular Weight

380.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes) .