OTX008
Product Specifications
UNSPSC Description
OTX008 is a selective inhibitor of galectin-1.
Target Antigen
Galectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/OTX008.html
Purity
99.09
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 33.33 mg/mL (ultrasonic)
Smiles
O=C(NCCN(C)C)COC1=C(C2)C=CC=C1CC3=C(OCC(NCCN(C)C)=O)C(CC4=CC=CC(CC5=CC=CC2=C5OCC(NCCN(C)C)=O)=C4OCC(NCCN(C)C)=O)=CC=C3
Molecular Weight
937.18
References & Citations
[1]Astorgues-Xerri L, et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur J Cancer. 2014 Sep;50(14):2463-77.|[2]Zucchetti M, et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19756/OTX008-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19756/OTX008-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
286936-40-1
Available Sizes
Curated Selection
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