OTX008

OTX008 is a selective inhibitor of galectin-1.

Product Specifications

CAS Number

[286936-40-1]

Product Name Alternative

Calixarene 0118; PTX008

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Galectin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/OTX008.html

Purity

99.94

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 33.33 mg/mL (ultrasonic)

Smiles

O=C(NCCN(C)C)COC1=C(C2)C=CC=C1CC3=C(OCC(NCCN(C)C)=O)C(CC4=CC=CC(CC5=CC=CC2=C5OCC(NCCN(C)C)=O)=C4OCC(NCCN(C)C)=O)=CC=C3

Molecular Formula

C52H72N8O8

Molecular Weight

937.18

Precautions

H315, H319

References & Citations

[1]Astorgues-Xerri L, et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur J Cancer. 2014 Sep;50 (14) :2463-77.|[2]Zucchetti M, et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother Pharmacol. 2013 Oct;72 (4) :879-87.