KR-30450

KR-30450 (SKP 450) is a potent K+ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255) . KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release[1].

Product Specifications

CAS Number

[172489-10-0]

Product Name Alternative

SKP 450

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kr-30450.html

Smiles

O=C1N(C2=C[C@](C)(C3OCCO3)OC4=CC=C([N+]([O-])=O)C=C24)CCC1

Molecular Formula

C17H18N2O6

Molecular Weight

346.33

References & Citations

[1]Jung YS, et al. Cardioprotective effects of KR-30450, a novel K+ (ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Jpn J Pharmacol. 1998 Jan;76 (1) :65-73.