(E/Z) -Sulindac sulfide

(E/Z) -Sulindac sulfide is a potent γ-secretase modulator (GSM) . (E/Z) -Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z) -Sulindac sulfide can be used for researching Alzheimer’s disease[1].

Product Specifications

CAS Number

[32004-67-4]

UNSPSC

12352005

Hazard Statement

H302, H317, H334, H361

Target

Amyloid-β; γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-z-sulindac-sulfide.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(CC(C(C=C(C=C1)F)=C1C2=CC3=CC=C(C=C3)SC)=C2C)O

Molecular Formula

C20H17FO2S

Molecular Weight

340.42

Precautions

H302, H317, H334, H361

References & Citations

[1]Richter L, et al. Amyloid beta 42 peptide (Abeta42) -lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107 (33) :14597-602.