Mavacamten

Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

Product Specifications

CAS Number

[1642288-47-8]

Product Name Alternative

MYK461; SAR439152

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Mavacamten.html

Purity

99.98

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CC(N(C1=O)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O)C

Molecular Formula

C15H19N3O2

Molecular Weight

273.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292 (40) :16571-16577.|[2]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11 (12) :e0168407.|[3]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351 (6273) :617-21.