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Guadecitabine sodium

Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) [1].

Product Specifications

CAS Number

[929904-85-8]

Product Name Alternative

SGI-110 sodium; S-110 sodium

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/S-110.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](COP(O[C@@H]4[C@@H](CO)O[C@@H](N5C=NC(N)=NC5=O)C4)(O[Na])=O)O3)C=N2)NC(N)=N1

Molecular Formula

C18H23N9NaO10P

Molecular Weight

579.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoo CB, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67 (13) :6400-8.|[2]Chuang JC, et al. S-110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9 (5) :1443-50.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

DNMT1

Citation 01

BioRxiv. 2024 August 09.|bioRxiv. 2025 February 08.|JID Innov. 2024 Oct 16;5 (2) :100319.|McGill University. 2025.|Research Square Print. January 3rd, 2023.|Cancer Res. 2020 Jul 15;80 (14) :3046-3056.|Epigenomes. 2021 Dec 14;5 (4) :27.|J Exp Clin Cancer Res. 2023 Mar 18;42 (1) :67.|J Transl Med. 2024 Mar 1;22 (1) :223.|Mol Cell. 2022 Oct 20;82 (20) :3901-3918.e7.|Neoplasia. 2020 May 25;22 (7) :274-282.|University of Siena. Department of Medical Biotechnologies. 2021 May.

Available Sizes

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