UNC3230

UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects[1].

Product Specifications

CAS Number

[1031602-63-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI4P5K

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/unc3230.html

Purity

99.39

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1)N

Molecular Formula

C17H20N4O2S

Molecular Weight

344.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Wright BD, et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014 May 21;82 (4) :836-47.|[2]Peng W, et al. Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine. 2019 Jun;44:375-386.|[3]Wright BD, et al. Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C. J Biomol Screen. 2015 Jun;20 (5) :655-62.