Schisandrol B

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities[1][2][3].

Product Specifications

CAS Number

[58546-54-6]

Product Name Alternative

Gomisin-A; TJN-101; Wuweizi alcohol-B

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Cytochrome P450; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Schisandrol-B.html

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@@]([C@@H](C)C1)(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC

Molecular Formula

C23H28O7

Molecular Weight

416.46

Precautions

H302

References & Citations

[1]Jiang Y, et al. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan;143 (1) :107-15.|[2]Jin J, et al. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharm Drug Dispos. 2010 May;31 (4) :264-8.|[3]Jeong-Seok Kim, et al. Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells. Clin Exp Pharmacol Physiol. 2018 Jun;45 (6) :547-555.