Clanfenur

Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication[1].

Product Specifications

CAS Number

[51213-99-1]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clanfenur.html

Purity

99.53

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC(C=C1)=CC=C1NC(NC(C2=C(C=CC=C2F)N(C)C)=O)=O

Molecular Formula

C16H15ClFN3O2

Molecular Weight

335.77

Precautions

H315, H319

References & Citations

[1]J D Jonkman-de Vries, et al. Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur. PDA J Pharm Sci Technol. 1997 Mar-Apr;51 (2) :89-95.