Clanfenur
Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication[1].
Product Specifications
CAS Number
51213-99-1
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clanfenur.html
Purity
99.53
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC=C1NC(NC(C2=C(C=CC=C2F)N(C)C)=O)=O
Molecular Formula
C16H15ClFN3O2
Molecular Weight
335.77
Precautions
H315, H319
References & Citations
[1]J D Jonkman-de Vries, et al. Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur. PDA J Pharm Sci Technol. 1997 Mar-Apr;51 (2) :89-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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