SIAH1 Recombinant Rabbit Monoclonal Antibody [PSH0-46]
E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene. This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
SIAH1, HUMSIAH
Swiss Prot
Q8IUQ4 Human, P61092 Mouse, Q920M9 Rat
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within human SIAH1 aa 1-50 / 282.
Isotype
IgG
Clone
PSH0-46
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:200-1:1,000 ;IF-Cell: 1:100 ;FC: 1:500-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 31.1 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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