Tubulin polymerization-IN-71
Tubulin polymerization-IN-71 (Compound 4k) is an inhibitor for tubulin polymerization with an IC50 of 3.06 μM. Tubulin polymerization-IN-71 inhibits the proliferation of cancer cell MG-63 and U2OS with IC50 of 0.08-0.14 μM. Tubulin polymerization-IN-71 arrests the cell cycle at G2/M phase, and induces apoptosis in MG-63[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-71.html
Smiles
O=C(C1=CC=C(C(F)=C1)OC)N(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC4=C(C=C3OC)OCO4
Molecular Formula
C25H24FNO8
Molecular Weight
485.46
References & Citations
[1]Chen Z, et al., Design and evaluation of novel N-substituent diphenylamine derivatives as tubulin colchicine binding site inhibitors. Bioorg Med Chem Lett. 2025 Jan 1;115:130031.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported