GW843682X
GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ～30 other kinases.
Product Specifications
CAS Number
660868-91-7
Product Name Alternative
GW843682
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GW843682X.html
Purity
99.89
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C(OCC2=CC=CC=C2C(F)(F)F)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N
Molecular Formula
C22H18F3N3O4S
Molecular Weight
477.46
Precautions
H315, H319, H335, H413
References & Citations
[1]Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther. 2007 Feb;6 (2) :450-9. Epub 2007 Jan 31.|[2]Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591 (1-3) :102-5.|[3]Ikezoe T, et al. A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23 (9) :1564-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1; PLK3
Available Sizes
Frequently Asked Questions
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