GW843682X

GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ～30 other kinases.

Product Specifications

CAS Number

[660868-91-7]

Product Name Alternative

GW843682

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H413

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GW843682X.html

Purity

99.89

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OCC2=CC=CC=C2C(F)(F)F)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N

Molecular Formula

C22H18F3N3O4S

Molecular Weight

477.46

Precautions

H315, H319, H335, H413

References & Citations

[1]Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther. 2007 Feb;6 (2) :450-9. Epub 2007 Jan 31.|[2]Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591 (1-3) :102-5.|[3]Ikezoe T, et al. A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23 (9) :1564-76.