RIPK3-IN-3
RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM) . RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].
Product Specifications
CAS Number
3052303-53-1
UNSPSC
12352005
Target
Mixed Lineage Kinase; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ripk3-in-3.html
Concentration
10mM
Purity
95.98
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C=CC1=NC=C2N=CN=C(NC3=CC(N=CS4)=C4C=C3)C2=C1
Molecular Formula
C16H11N5S
Molecular Weight
305.36
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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