RIPK3-IN-3

RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM) . RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].

Product Specifications

CAS Number

[3052303-53-1]

UNSPSC

12352005

Target

Mixed Lineage Kinase; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ripk3-in-3.html

Concentration

10mM

Purity

95.98

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=CC1=NC=C2N=CN=C(NC3=CC(N=CS4)=C4C=C3)C2=C1

Molecular Formula

C16H11N5S

Molecular Weight

305.36

References & Citations

[1]Namkyoung Kim, et al. Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors. Eur J Med Chem. 2023, 259, 115635.|[2]Kim N, et al. Identification of Pyrido [3, 4-d] pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors[J]. European Journal of Medicinal Chemistry, 2023, 259: 115635...