N-Acetyl mesalazine

N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027) . N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer[1][2][3].

Product Specifications

CAS Number

[51-59-2]

Product Name Alternative

N-Acetyl-5-aminosalicylic acid; N-Acetyl-ASA

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-acetyl-mesalazine.html

Purity

99.91

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(NC(C)=O)=CC=C1O

Molecular Formula

C9H9NO4

Molecular Weight

195.17

Precautions

H302, H319

References & Citations

[1]Allgayer H, et al. Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer. Dig Dis Sci. 1999 Apr;44 (4) :761-7.|[2]Fukuda T, et al. Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine. J Gastroenterol Hepatol. 2020 Nov;35 (11) :1878-1885.|[3]Willoughby CP, et al. The effect of topical N-acetyl-5-aminosalicylic acid in ulcerative colitis. Scand J Gastroenterol. 1980;15 (6) :715-9.