Ibudilast

Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1].

Product Specifications

CAS Number

[50847-11-5]

Product Name Alternative

KC-404; AV-411; MN-166

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Ibudilast.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 140 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O

Molecular Formula

C14H18N2O

Molecular Weight

230.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46 (3) :404-11.