PELP1-IN-1

PELP1-IN-1 is a PELP1 inhibitor. SMIP34 reduces cell viability and colony formation. PELP1-IN-1 induces apoptosis and cell cycle arrest at S phase. PELP1-IN-1 decreases the expression of PELP1. PELP1-IN-1 shows antitumor activity. SMIP34 has the potential for the research of triple-negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[946262-80-2]

UNSPSC

12352101

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smip34.html

Purity

98.99

Solubility

DMSO : 4.57 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(N(C3=CC=C(Cl)C=C3)N=C2)N=C(SCC(NCC4=CC=C(F)C=C4)=O)N1

Molecular Formula

C20H15ClFN5O2S

Molecular Weight

443.88

References & Citations

[1]Altwegg KA, et al. Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34. Breast Cancer Res Treat. 2023 Jul;200 (1) :151-162.