YT 146
YT 146 is a potent agonist of A2 adenosine receptor (A2 AR) agonist. YT 146 causes a concentreation dependent cAMP accumulation, with the EC50 of 1.5 nM. YT 146 has cardioprotective effects[1].
Product Specifications
CAS Number
90596-75-1
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/yt-146.html
Purity
99.72
Smiles
O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C3=NC(C#CCCCCCC)=NC(N)=C3N=C2
Molecular Formula
C18H25N5O4
Molecular Weight
375.42
References & Citations
[1]Jun Sasamori, et al. Cardioprotective effects of 2-octynyladenosine (YT-146) in ischemic/reperfused rat hearts. J Cardiovasc Pharmacol. 2011 Feb;57 (2) :166-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Adenosine A2A receptor (A2AR)
Available Sizes
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