Zuclopenthixol
Zuclopenthixol ((Z) -Clopenthixol) is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].
Product Specifications
CAS Number
[53772-83-1]
Product Name Alternative
(Z) -Clopenthixol
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Zuclopenthixol.html
Purity
98.08
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(Cl)=C3)CC1
Molecular Formula
C22H25ClN2OS
Molecular Weight
400.96
Precautions
H315, H319, H320
References & Citations
[1]Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21 (1) :11-5.|[2]Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23 (9) :439-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor
Curated Selection
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