RO5353
RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice[1].
Product Specifications
CAS Number
[1360821-61-9]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ro5353.html
Smiles
NC(C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C(SC(Cl)=C5)=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=C1)=O
Molecular Formula
C29H29Cl2FN4O4S
Molecular Weight
619.53
References & Citations
[1]Zhang Z, et al., Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5 (2) :124-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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