RO5353
Product Specifications
UNSPSC Description
RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice[1].
Target Antigen
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ro5353.html
Smiles
NC(C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C(SC(Cl)=C5)=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=C1)=O
Molecular Weight
619.53
References & Citations
[1]Zhang Z, et al., Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12580/RO5353-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12580/
Clinical Information
No Development Reported
CAS Number
1360821-61-9
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