Vacquinol-1 (dihydrochloride)
Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 dihydrochloride specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC) cell[3].
Product Specifications
CAS Number
2309312-85-2
Product Name Alternative
NSC13316 (dihydrochloride)
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vacquinol-1-dihydrochloride.html
Purity
99.70
Solubility
DMSO : 25 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl
Molecular Formula
C21H23Cl3N2O
Molecular Weight
425.78
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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