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Anti-Mouse TIM-1/CD365 Antibody (3B3)

Anti-Mouse TIM-1/CD365 Antibody (3B3) is a rat-derived IgG2a κ type agonistic antibody, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3B3) enhances T-cell proliferation and responses by forming a stable TIM-1 complex and bringing TIM-1 into the T-cell receptor (TCR) -CD3 complex. Anti-Mouse TIM-1/CD365 Antibody (3B3) can be used for the researches of cancer, inflammation and immunology, such as experimental autoimmune encephalomyelitis, B16 F10 tumor and transplant[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

Transmembrane Glycoprotein

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-tim-1-cd365-antibody-3b3.html

Solubility

10 mM in DMSO

Smiles

[Anti-MouseTIM-1/CD365Antibody(3B3)]

Molecular Weight

(150 kDa)

References & Citations

[1]Umetsu SE, et al. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005 May;6 (5) :447-54.|[2]Tian X, et al. B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy. Signal Transduct Target Ther. 2023 Oct 20;8 (1) :389.|[3]Xiao S, et al. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 9;204 (7) :1691-702.|[4]Degauque N, et al. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest. 2008 Feb;118 (2) :735-41.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

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