Exatecan Intermediate 6
Product Specifications
UNSPSC Description
Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).
Target Antigen
ADC Cytotoxin; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-6.html
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O
Molecular Weight
235.258
References & Citations
[1]Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-44369/Exatecan-Intermediate-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-44369/Exatecan-Intermediate-6-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
143655-58-7
Available Sizes
Curated Selection
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