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Anti-Mouse CSF1R/CD115 Antibody (AFS98)

Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

C-Fms

Type

Inhibitory Antibodies

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/anti-mouse-csf1r-cd115-antibody-afs98.html

Purity

99.38

Solubility

10 mM in DMSO

Smiles

[Anti-MouseCSF1R/CD115Antibody(AFS98)]

Molecular Weight

(150 kDa)

References & Citations

[1]Marino Lee S, et al. Microglia depletion increase brain injury after acute ischemic stroke in aged mice. Exp Neurol. 2021 Feb;336:113530.|[2]Lim AK, et al. Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. Diabetologia. 2009 Aug;52 (8) :1669-79.|[3]Murayama T, et al. Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice. Circulation. 1999 Apr 6;99 (13) :1740-6.|[4]Toh ML, et al. Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis. Arthritis Rheumatol. 2014 Nov;66 (11) :2989-3000.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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